Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin
Identifieur interne : 001911 ( Main/Exploration ); précédent : 001910; suivant : 001912Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin
Auteurs : Darryl Falzarano ; Emmie De Wit ; Cynthia Martellaro ; Julie Callison ; Vincent J. Munster [États-Unis] ; Heinz FeldmannSource :
- Scientific Reports [ 2045-2322 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Interféron alpha, Ribavirine.
- physiologie : Coronavirus, Réplication virale.
- Animaux, Association médicamenteuse, Cellules Vero, Coronavirus, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Interferon-alpha, Ribavirin.
- chemical : Drug Combinations.
- drug effects : Coronavirus, Virus Replication.
- physiology : Coronavirus, Virus Replication.
- Animals, Chlorocebus aethiops, Vero Cells.
Abstract
The identification of a novel β coronavirus, nCoV, as the causative agent of severe respiratory illness in humans originating in Saudi Arabia, Qatar and Jordan has raised concerns about the possibility of a coronavirus pandemic similar to that of SARS-CoV. As a definitive treatment regimen has never been thoroughly evaluated for coronavirus infections, there is an urgent need to rapidly identify potential therapeutics to address future cases of nCoV. To determine an intervention strategy, the effect of interferon-α2b and ribavirin on nCoV isolate hCoV-EMC/2012 replication in Vero and LLC-MK2 cells was evaluated. hCoV-EMC/2012 was sensitive to both interferon-α2b and ribavirin alone in Vero and LLC-MK2 cells, but only at relatively high concentrations; however, when combined, lower concentrations of interferon-α2b and ribavirin achieved comparable endpoints. Thus, a combination of interferon-α2b and ribavirin, which are already commonly used in the clinic, may be useful for patient management in the event of future nCoV infections.
Url:
DOI: 10.1038/srep01686
PubMed: 23594967
PubMed Central: 3629412
Affiliations:
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As a definitive treatment regimen has never been thoroughly evaluated for coronavirus infections, there is an urgent need to rapidly identify potential therapeutics to address future cases of nCoV. To determine an intervention strategy, the effect of interferon-α2b and ribavirin on nCoV isolate hCoV-EMC/2012 replication in Vero and LLC-MK2 cells was evaluated. hCoV-EMC/2012 was sensitive to both interferon-α2b and ribavirin alone in Vero and LLC-MK2 cells, but only at relatively high concentrations; however, when combined, lower concentrations of interferon-α2b and ribavirin achieved comparable endpoints. Thus, a combination of interferon-α2b and ribavirin, which are already commonly used in the clinic, may be useful for patient management in the event of future nCoV infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchholz, U" uniqKey="Buchholz U">U Buchholz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wise, J" uniqKey="Wise J">J 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uniqKey="Oostrom Ram T">T Oostrom-Ram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wills, Rj" uniqKey="Wills R">RJ Wills</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hausfater, P" uniqKey="Hausfater P">P Hausfater</name></author><author><name sortKey="Cacoub, P" uniqKey="Cacoub P">P Cacoub</name></author><author><name sortKey="Assogba, U" uniqKey="Assogba U">U Assogba</name></author><author><name sortKey="Lebon, P" uniqKey="Lebon P">P Lebon</name></author><author><name sortKey="Piette, Jc" uniqKey="Piette J">JC Piette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, Lj" uniqKey="Reed L">LJ Reed</name></author><author><name sortKey="Muench, Ha" uniqKey="Muench H">HA Muench</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Montana</li></region></list><tree><noCountry><name sortKey="Callison, Julie" sort="Callison, Julie" uniqKey="Callison J" first="Julie" last="Callison">Julie Callison</name><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><name sortKey="Martellaro, Cynthia" sort="Martellaro, Cynthia" uniqKey="Martellaro C" first="Cynthia" last="Martellaro">Cynthia Martellaro</name></noCountry><country name="États-Unis"><region name="Montana"><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. 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